Ultrasound-assisted ex vivo transdermal test of glucosamine sulfate solution / 南方医科大学学报
Journal of Southern Medical University
;
(12): 746-749, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-306475
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the transdermal permeability of glucosamine sulfate solution across ex vivo rabbit dermis under ultrasound and optimize the ultrasound conditions.</p><p><b>METHODS</b>The ultrasound-assisted transdermal permeation of glucosamine sulfate solution across ex vivo rabbit dermis was tested using a simple Franz diffuse. The transdermal permeation volume and rate were calculated by measuring the concentration of glucosamine sulfate in the receptor fluid with ultraviolet spectrophotometry, and the impact of different sound intensities, irradiation time and solution concentration on solution permeation was analyzed.</p><p><b>RESULTS</b>At the ultrasound intensity of 0.2 W/cm(2), the permeation volume and rate of glucosamine sulfate both reached the maximum; no glucosamine sulfate was detected in the receptor fluid after a 5-min ultrasound irradiation. The permeation volume and rate of glucosamine sulfate increased as the irradiation time prolonged and also with increased glucosamine sulfate concentration. The dorsal and lateral skin thickness (2.0∓0.1 and 1.2∓0.1 mm, respectively) did not significantly affect the transdermal permeation of glucosamine sulfate (P>0.05).</p><p><b>CONCLUSION</b>Ultrasound irradiation at 1.0 MHz for over 5 min allows glucosamine sulfate to permeate rabbit dermis, and the volume and rate of permeation increase with the irradiation time and concentration of the solution and are not affected by variations of the dermal thickness.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Skin Absorption
/
Ultrasonics
/
In Vitro Techniques
/
Administration, Cutaneous
/
Diagnostic Imaging
/
Ultrasonography
/
Dermis
/
Glucosamine
/
Metabolism
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS