Epidermal growth factor receptor and ligands in pancreatic beta-cell / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 203-207, 2011.
Article
in Zh
| WPRIM
| ID: wpr-306592
Responsible library:
WPRO
ABSTRACT
Epidermal growth factor receptor (EGFR) cell signaling plays a central role in beta-cell mass/function regulation, and provides a new strategy for the treatment of diabetes, but its mechanisms of action remain poorly understood. In developmental biology, pancreatic islet development is impaired in lacking EGFR of mice. The attenuation of EGFR signaling in the islets leads to markedly reduced beta-cell proliferation. EGFR ligands BTC can increase proliferation and neogenesis. In this article EGFR and their ligands in the pancreas, EGFR cell signaling, and EGFR effects in pancreatic beta-cell mass/function regulation were reviewed.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Signal Transduction
/
Intercellular Signaling Peptides and Proteins
/
Insulin-Secreting Cells
/
ErbB Receptors
/
Betacellulin
/
Ligands
/
Metabolism
Limits:
Humans
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2011
Type:
Article