Progress of nanometer vector polyethylenimine applied in gene therapy / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 195-198, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-306594
ABSTRACT
Polyethylenimine (PEI) is a kind of nanometer nonviral vector frequently applied in gene transfection. It is simple and easy to prepare and to modify and relatively safe compared to viral vectors. In recent years, PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain. This review reveals that the cytotoxicity and low transfection efficiency of PEI requires to be improved. However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyethyleneimine
/
Transfection
/
Genetic Therapy
/
Chemistry
/
Stem Cell Transplantation
/
Nanostructures
/
Genetic Vectors
/
Methods
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2011
Type:
Article
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