The experimental results of GVHD following orthotropic liver transplantation / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 856-860, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-306628
ABSTRACT
<p><b>OBJECTIVE</b>To analyze experimental results of Graft-versus-host disease (GVHD) after liver transplantation.</p><p><b>METHODS</b>13 cases of GVHD out of the 1013 liver transplantation between 2002-2008 were analysed. Routine blood test, liver function and microorganisms test were done in all of the 13 cases, bone marrow test was done in 5 cases, liver pathological test was done in 5 cases, cytokines were analyzed in 4 cases, chimerism test was done in 6 cases.</p><p><b>RESULTS</b>Leukocytes were reduced to various degree in all 13 cases, and were extremely low in 8 cases. Hematopoiesis was repressed in 4 cases. Normal liver function was found in 9 cases. Bacterium were found in blood, bile, wound secrete juice, excrement, phlegm of 10 cases. The pathological characteristics was in accordance with GVHD in 5 cases. The levels of IL-1 alpha, IL-1 beta, IL-2, IL-4 were low or undetectable. IL-10 was decreased in 4 cases but increased in 1 case. MCP-1, VEGF, IL-6, EGF, IL-8 were increasing or remained at high level during GVHD. TNF alpha was slightly increased. IFN gamma was only slightly changed before GVHD.</p><p><b>CONCLUSION</b>Chimerism is a reliable but not unique evidence of GVHD.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacterial Infections
/
Transplantation, Autologous
/
Blood
/
Bone Marrow Diseases
/
Bone Marrow Examination
/
Acute Disease
/
Retrospective Studies
/
Mortality
/
Cause of Death
/
Cytokines
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2009
Type:
Article
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