Association of Hospital Procedure Volume with Post-Transplant Survival for Allogeneic Bone Marrow Transplantation / 예방의학회지
Korean Journal of Preventive Medicine
;
: 26-36, 2004.
Article
in Korean
| WPRIM
| ID: wpr-30687
ABSTRACT
OBJECTIVE:
To examine the association between hospital procedure volume and treatment outcomes following allogeneic bone marrow transplantation (allo-BMT).METHODS:
Out of 1, 050 patients who received allo-BMTs between 1998 and 2000 in 21 Korean hospitals, 752 with first allo-BMT and complete data were included in this study. Study subjects were divided into the following three groups according to cumulative hospital experience of all-BMTs during the study period low ( or =50 cases) volume. Patient outcome was defined as early survival at day 100 and one-year survival. Multiple logistic regression analyses were performed to examine the association between hospital experience and survival at day 100 and one year.RESULTS:
When the low volume group was defined as the reference group, the adjusted relative risks (RR) of survival at day 100 for the high volume group were 2.46 (95% CI, 1.13-5.36) for all patients, 2.61 (1.04-6.57) for those with leukemia, and 2.20 (0.47-10.32) for those with aplastic anemia. For one-year survival, adjusted RR for the high volume group were 2.52 (1.40-4.51) for all patients, 1.99 (1.01-3.93) for leukemia, and 6.50 (1.57-26.80) for aplastic anemia. None of the RR for the medium volume group was statistically significant. Patient factors showing significant relationship with survival were donor-recipient relation, human leukocyte antigen matching status, time from diagnosis to transplant, and disease stage.CONCLUSION:
The study results suggest that the cumulative experience of hospitals in providing allo-BMT is positively associated with patient survival.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Leukemia
/
Logistic Models
/
Bone Marrow Transplantation
/
Diagnosis
/
Anemia, Aplastic
/
Leukocytes
Type of study:
Diagnostic study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
2004
Type:
Article
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