Effect of exposure to trace elements in the soil on the prevalence of neural tube defects in a high-risk area of China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 94-101, 2011.
Article
in English
| WPRIM
| ID: wpr-306885
ABSTRACT
<p><b>OBJECTIVE</b>Our objective is to build a model that explains the association between the exposure to trace elements in the soil and the risk of neural tube defects.</p><p><b>METHODS</b>We built a function with different parameters to describe the effects of trace elements on neural tube defects. The association between neural tube defects and trace element levels was transformed into an optimization problem using the maximum likelihood method.</p><p><b>RESULTS</b>Tin, lead, nickel, iron, copper, and aluminum had typical layered effects (dosage effects) on the prevalence of neural tube defects. Arsenic, selenium, zinc, strontium, and vanadium had no effect, and molybdenum had one threshold value that affected the prevalence of birth defects.</p><p><b>CONCLUSION</b>As an exploratory research work, our model can be used to determine the direction of the effect of the trace element content of cultivated soil on the risk of neural tube defects, which shows the clues by the dosage effect of their toxicological characteristics. Based on our findings, future biogeochemical research should focus on the direct effects of trace elements on human health.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Soil Pollutants
/
Trace Elements
/
Chemistry
/
China
/
Epidemiology
/
Prevalence
/
Dose-Response Relationship, Drug
/
Environmental Exposure
/
Toxicity
/
Metals
Type of study:
Etiology study
/
Prevalence study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2011
Type:
Article
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