Protective effect of velvet antler polypeptide (VAP) on rats with the spinal cord injury / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 285-286, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-307030
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of antler polypeptide on the rats with spinal cord injury (SCI).</p><p><b>METHODS</b>The model rats were treated with different doses of antler polypeptide, and its effect on motor function, ethology and pathological changes of spinal cord of the rats observed.</p><p><b>RESULTS</b>Seven days after treatment with different doses of antler polypeptide, rat's motor activity was recovered in some extent. Significant difference (P < 0.001)was found between the antler polypeptide treatment group and operation group. The effect could be enhanced by increase of the doses. We observerd the effect on the pathological change of spinal cord in rat, and found the tissue edema and inflammatory infiltration were relieved after treatment with different doses of antler polypeptide, especially in the dose of 15 mg antler polypeptide.</p><p><b>CONCLUSION</b>Antler polypeptide can promote the motor function recovery in SCI rats, and its action is dose-dependent.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antlers
/
Pathology
/
Peptides
/
Spinal Cord
/
Spinal Cord Injuries
/
Chemistry
/
Rats, Wistar
/
Therapeutic Uses
/
Drug Therapy
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2008
Type:
Article
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