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Increased plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 719-722, 2007.
Article in Chinese | WPRIM | ID: wpr-307213
ABSTRACT
<p><b>OBJECTIVE</b>This study investigates the plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients.</p><p><b>METHODS</b>Patients were scruited according to JNC-7 and divided into three groups 74 normotensive subjects (NT group, 38 males, mean age 47.15 +/- 7.77 years old); 51 prehypertensive patients (PH group, 29 males, mean age 47.82 +/- 5.16 years old) and 71 essential hypertensive patients (EH group, 37 males, mean age 48.25 +/- 7.97 years old). Serum lipids and plasma angiotensin II (Ang II), endothelin (ET), vasopressin (AVP), calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GPX) by radioimmunoassay and enzyme linked immunosorbent assay.</p><p><b>RESULTS</b>Serum Lipids (TG, CHO and LDL) were significantly higher in the PH and EH groups compared to NT group (all P < 0.05). Ang II, AVP and ET were significantly increased while CGRP decreased in the EH group than that in NT group (all P < 0.05). SOD was significantly lower while GPX significantly higher. Further more, in the PH and EH groups than those in the NT group (all P < 0.05).</p><p><b>CONCLUSION</b>SOD was reduced and GPX increased in prehypertensive patients.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Plasma / Superoxide Dismutase / Blood / Blood Pressure / Angiotensin II / Vasopressins / Calcitonin Gene-Related Peptide / Case-Control Studies / Endothelins Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Cardiology Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Plasma / Superoxide Dismutase / Blood / Blood Pressure / Angiotensin II / Vasopressins / Calcitonin Gene-Related Peptide / Case-Control Studies / Endothelins Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Cardiology Year: 2007 Type: Article