Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 652-654, 2007.
Article
in Zh
| WPRIM
| ID: wpr-307226
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients.</p><p><b>METHOD</b>Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin.</p><p><b>RESULTS</b>TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01).</p><p><b>CONCLUSION</b>C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Vitamin K 1
/
Warfarin
/
International Normalized Ratio
/
Polymorphism, Single Nucleotide
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Asian People
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Dose-Response Relationship, Drug
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Vitamin K Epoxide Reductases
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Genetics
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Genotype
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Mixed Function Oxygenases
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2007
Type:
Article