Expressions of beta(3)-adrenoceptor and peroxisome proliferator-activated receptor alpha in human failing heart / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 607-610, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-307237
ABSTRACT
<p><b>OBJECTIVE</b>To explore the changes on the content of substrate, the activity of correlative enzyme and the mRNA and protein expressions of beta(3)-adrenoceptor and peroxisome proliferator-activated receptor alpha (PPARalpha) in human failing heart.</p><p><b>METHOD</b>Papillary muscles from 20 patients with heart failure during mitral valves replacement and 6 control subjects died of non-cardiac accidents were obtained and free fat acid (FFA), lactic acid (LD) and the activity of Na(+)K(+)-ATPase and Ca(2+)Mg(2+)-ATPase, protein and mRNA expressions of beta(3)-adrenergic receptor and PPARalpha were measured.</p><p><b>RESULT</b>In the failing heart, the contents of fat acid, LD and expression of beta(3)-adrenoceptor mRNA and protein were significantly higher while the activity of Na(+)K(+)-ATPase and Ca(2+)Mg(2+)-ATPase, expressions of PPARalpha at mRNA and protein levels were significantly lower than those in control myocardium.</p><p><b>CONCLUSION</b>Metabolic remodeling (upregulation of beta(3)-adrenoceptor and downregulation of PPARalpha) might contribute to the pathophysiology of heart failure.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Adrenergic, beta-3
/
PPAR alpha
/
Heart Failure
/
Metabolism
/
Myocardium
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2007
Type:
Article
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