Expression of MICA/B protein in esophageal cancer and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 745-747, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-307302
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.</p><p><b>METHODS</b>The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.</p><p><b>RESULTS</b>The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).</p><p><b>CONCLUSION</b>MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Esophageal Neoplasms
/
Immunohistochemistry
/
Histocompatibility Antigens Class I
/
Biomarkers, Tumor
/
Up-Regulation
/
Diagnosis
/
Neoplasm Grading
/
Metabolism
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS