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Expression of MICA/B protein in esophageal cancer and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 745-747, 2012.
Article in Chinese | WPRIM | ID: wpr-307302
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.</p><p><b>METHODS</b>The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.</p><p><b>RESULTS</b>The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).</p><p><b>CONCLUSION</b>MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Esophageal Neoplasms / Immunohistochemistry / Histocompatibility Antigens Class I / Biomarkers, Tumor / Up-Regulation / Diagnosis / Neoplasm Grading / Metabolism Type of study: Diagnostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Esophageal Neoplasms / Immunohistochemistry / Histocompatibility Antigens Class I / Biomarkers, Tumor / Up-Regulation / Diagnosis / Neoplasm Grading / Metabolism Type of study: Diagnostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2012 Type: Article