Expression of erythropoietin and erythropoietin receptor in non-small cell lung cancer and its correlation with microvessel density / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 605-608, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-307333
ABSTRACT
<p><b>OBJECTIVE</b>Erythropoietin and erythropoietin receptor (EPO-R) are expressed in many kinds of tumors. The EPO/EPO-R signaling is involved in tumor cell proliferation, invasion and angiogenesis. The aim of this study was to detect the expression of EPO-R in non-small cell lung cancer (NSCLC), and explore its correlation with angiogenesis.</p><p><b>METHODS</b>The expression patterns of EPO and EPO-R in 31 cases of NSCLC tissues were detected by immunohistochemistry, and that in benign lung lesions of 21 patients as control. To analyze the correlation of EPO/EPO-R expression patterns and clinicopathological factors. CD34 was used to label the vascular endothelial cells and calculate the microvessel density (MVD).</p><p><b>RESULTS</b>The positive rates of EPO and EPO-R expression in NSCLC were 67.7% and 96.8%, respectively, significantly higher than those in the control ones. The positive rates of EPO and EPO-R expression in adjacent tissues were 19.4% and 35.5%, and in benign lesions were 9.5% and 19.0%, respectively (P < 0.001). The expression patterns of EPO/EPO-R were not related with pTNM stage, histological type, histological grade and lymph node metastasis (P > 0.05). Increased MVD was correlated with poor differentiation, lymph node metastasis, and advanced stage.</p><p><b>CONCLUSIONS</b>High expression of EPO/EPO-R in NSCLC patients suggest that they may be involved in tumorigenesis. EPO/EPO-R expression and MVD are closely related, and they might be an endogenous stimulant of angiogenesis during the progression of non-small cell lung cancer. It may provide evidence for clinical diagnosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Erythropoietin
/
Receptors, Erythropoietin
/
Carcinoma, Non-Small-Cell Lung
/
Antigens, CD34
/
Microvessels
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Metabolism
/
Neoplasm Staging
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2012
Type:
Article
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