Preparation of sinomenine microemulsion and its transdermal absorption / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2007-2010, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-307543
ABSTRACT
<p><b>OBJECTIVE</b>To screen the optimum formulation and prepare O/W sinomenine microemulsion and investigate its in vitro transdermal delivery ability.</p><p><b>METHOD</b>The microemulsions were prepared with the formulation containing oleic acid-tween 80-dehydrated alcohol-water by the pseudo-ternary phase diagram. The permeation flux of sinomenine was determined in vitro by Franz diffusion cell fitted with rat skin. The sinomenine was determined by HPLC. The transdermal characteristics of sinomenine microemulsion were compared with that of sinomenine gels.</p><p><b>RESULT</b>The steady state flux of sinomenine microemulsion was significantly higher than that of sinomenine gels. The average permeation rate of sinomenine microemulsion was 116. 44 microg x cm(-2) x h(-1) in vitro.</p><p><b>CONCLUSION</b>These results indicated that the studied microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of sinomenine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Plants, Medicinal
/
Polysorbates
/
Skin
/
Skin Absorption
/
Surface-Active Agents
/
Administration, Cutaneous
/
Pharmacokinetics
/
Chemistry
/
Drug Delivery Systems
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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