Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2322-2324, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-307593
ABSTRACT
<p><b>OBJECTIVE</b>To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).</p><p><b>METHOD</b>The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.</p><p><b>RESULT</b>The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.</p><p><b>CONCLUSION</b>The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Polyesters
/
Polymers
/
Strychnine
/
Drug Carriers
/
Drugs, Chinese Herbal
/
Kinetics
/
Chemistry
/
Drug Delivery Systems
/
Lactic Acid
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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