Chemical constituents and bioactivity of Teucrium pilosum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2189-2193, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-307622
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents and bioactivity of Teurium pilosum.</p><p><b>METHOD</b>Various column chromatographic techniques were used to isolate the constituents. A combination of EI-MS, NMR spectroscopy and X-Ray were applied to identify the structures. The anti-microorganism was accomplished by disk diffusion method, the antioxidant activity was assayed by the DPPH microanalysis models and the inhibitory activity of alpha-glucosidase was screened In vitro.</p><p><b>RESULT</b>Eight compounds were isolated and identified as glyceryl tristearate (1), 2,5-dioxolanone (2), fernenol (3), stigmasta-5,22-dien-3P-ol (4), 24-nor cholesta-5,22 (E)-dien-3beta-ol (5), ca-spinasterol (6), (3,4-dihydroxyphenyl) acrylate (7), 3,4-dihydroxy phenyl acrylic acid (8).</p><p><b>CONCLUSION</b>All compounds have been isolated from the genus for the first time. Compound 3 [IC50 = (37.63 +/- 3.45) mg +/- L(-1)], 6 [IC50 = (178.92 +/- 4.99) mg x L(-1)] and 8 [IC50 = (44.32 +/- 7.02) mg x L(-1)] are of higher inhibitory alpha-glucosidase activity than that of acarbose [IC50 = (1081.27 +/- 12.3) mg x L(-1)]. Compound7 [IC50 = (4.81 +/- 0.96) mg x L(-1)] and 8 [IC50 = (4.16 +/- 0.11) mg L(-1)] showed higher antioxidant activity than that of BHT [IC50 = (35.64 +/- 0.36) mg x L(-1)] and BHA [IC50 = (8.74 +/- 0.39) mg x L(-1)]. Compound 5-8 exhibited inhibitory activity against Fusarium graminearum. Compound 5 and 8 showed inhibitory activity against Botrytis cinerea.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plant Extracts
/
Chemistry
/
Teucrium
/
Enzyme Inhibitors
/
Alpha-Glucosidases
/
Glycoside Hydrolase Inhibitors
/
Fusarium
/
Antifungal Agents
/
Antioxidants
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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