STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine / 南方医科大学学报
Journal of Southern Medical University
;
(12): 256-258, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-307957
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells.</p><p><b>METHODS</b>The growth of HepG2 cells exposed to 0.125, 0.25, 0.5 and 1.0 mmol/L PE was assessed by MTT assay, and the expressions of STAT1 and STAT2 were analyzed using immunocytochemical assay.</p><p><b>RESULTS</b>PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. AG490, an inhibitor of JAKs, partially reversed PE-induced growth inhibition of HepG2 cells.</p><p><b>CONCLUSION</b>STAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phosphatidylethanolamines
/
Apoptosis
/
Cell Proliferation
/
STAT1 Transcription Factor
/
STAT2 Transcription Factor
/
Hep G2 Cells
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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