Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
The Korean Journal of Internal Medicine
;
: 443-449, 2015.
Article
in English
| WPRIM
| ID: wpr-30797
ABSTRACT
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered to have asthma-COPD overlap syndrome (ACOS). However, patients regarded to have ACOS by spirometric criteria alone are heterogeneous and can be classified by phenotype. Eosinophilic inflammation, a history of allergic disease, and smoke exposure are important components in the classification of ACOS. Each phenotype has a different underlying pathophysiology, set of characteristics, and prognosis. Medical treatment for ACOS should be tailored according to phenotype. A narrower definition of ACOS that includes both spirometric and clinical criteria is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Asthma
/
Spirometry
/
Syndrome
/
Bronchodilator Agents
/
Predictive Value of Tests
/
Risk Factors
/
Treatment Outcome
/
Anti-Asthmatic Agents
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS