Association of interleukin-18 gene polymorphism with genetic susceptibility to systematic lupus erythematosus in Guangxi Zhuang population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 434-437, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-308045
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the single nucleotide polymorphisms of interleukin-18 (IL-18) gene with the susceptibility to systematic lupus erythematosus (SLE) in a Chinese Zhuang population.</p><p><b>METHODS</b>Two single nucleotide polymorphisms of the IL-18 gene promoter were analyzed, namely -137G/C and -607C/A, in 115 patients with SLE and 160 age and sex-matched controls in a Chinese Zhuang population, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and DNA sequencing.</p><p><b>RESULTS</b>The IL-18 gene -607C/A polymorphism was significantly different between the SLE and control group (P < 0.05). The relative risk of SLE for -607C allele carrier was 1.619 times of the -607A allele carriers (OR=1.619, 95%CI 1.150-2.281). Consistent with the results of the genotyping analyses, IL-18 -137G/-607C allele frequencies in patients with SLE was significant higher than that in controls (P < 0.05). The -137G/-607C allele was associated with a significantly increased risk of SLE (OR=1.484, 95%CI 1.056-2.087). However, there was no difference of the distributions of the -137G/C polymorphism of the IL-18 gene between the SLE and control groups.</p><p><b>CONCLUSION</b>IL-18 gene -607C/A polymorphism was associated with SLE, the -607C allele may be a risk factor for SLE.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Risk Factors
/
Genetic Predisposition to Disease
/
Interleukin-18
/
Polymorphism, Single Nucleotide
/
Population Groups
/
Asian People
/
Alleles
/
Gene Frequency
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2008
Type:
Article
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