Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs).</p><p><b>METHODS</b>Twelve SHRs were randomly divided into two groups. Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen.</p><p><b>RESULTS</b>The pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction.</p><p><b>CONCLUSION</b>Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle.</p>