A new vomiting animal model--mink / 药学学报

ABSTRACT

<p><b>AIM</b>To establish a new, reliable vomiting model in minks.</p><p><b>METHODS</b>Adult male minks (Mustela vison) were randomly divided into groups (n = 6). Cisplatin, apomorphine, copper sulfate and X-radiation were used to establish vomiting model. Retching and vomiting were observed after the vomiting models were given anti-vomiting agents. After the behavioral experiment, assay of 5-HT in the ileum was performed by immunohistologic method.</p><p><b>RESULTS</b>Cisplatin 7.5 mg.kg-1 i.p., apomorphine 1.6 mg.kg-1 s.c. and copper sulfate 40 mg.kg-1 ig were shown to evoke vomiting. Retching and vomiting were significantly inhibited in ondansetron and metoclopramide pretreated minks (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>As a new vomiting model, minks may be of great value in studying vomiting mechanism and screening new antiemetic drugs.</p>