Effect of injection of testosterone undecanoate and depot medroxyprogesterone acetate on the suppression of spermatogenesis / 中华男科学杂志
National Journal of Andrology
;
(12): 572-581, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-308298
ABSTRACT
<p><b>OBJECTIVE</b>To observe depot medroxyprogesterone acetate (DMPA) and testosterone undecanoate (TU) injected at 8-week intervals for the suppression of spermatogenesis in healthy Chinese men.</p><p><b>METHODS</b>After screening, 30 healthy volunteers were enrolled and randomly assigned to 3 dosage-groups (n = 10/group) 1000 mg TU (Group A), 1000 mg TU plus 150 mg DMPA (Group B), 1000 mg TU plus 300 mg DMPA (Group C). All dosages were given as intramuscular injections at 8-week intervals. The study consisted of an 8-week control (baseline) period, a 24-week treatment period and a 24-week recovery period.</p><p><b>RESULTS</b>Consistent azoospermia or severe oligozoospermia was achieved and maintained in all the volunteers during the treatment period, except 2 in the mere TU group who experienced a "rebound" in sperm concentrations. An 8-week regimen of TU plus DMPA at both tested combination dosages effectively suppressed spermatogenesis to azoospermia. All volunteers tolerated the injections; no serious adverse effects were reported.</p><p><b>CONCLUSION</b>The lower combined dosage is recommended for further testing in an expanded clinical trial or contraceptive efficacy study.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sperm Count
/
Spermatogenesis
/
Testosterone
/
China
/
Prospective Studies
/
Gonadotropin-Releasing Hormone
/
Medroxyprogesterone Acetate
/
Hypothalamo-Hypophyseal System
/
Androgens
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2004
Type:
Article
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