Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 25-27, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-308430
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of quercetin on cell morphology and VEGF expression of acute myeloblastic leukemia cells NB4 in vitro.</p><p><b>METHODS</b>The cytomorphology of NB4 cells was assessed by Wright-stain, apoptosis rate by apoptotic marker Annexin V, and VEGF secretion level by ELISA.</p><p><b>RESULTS</b>Typical apoptosis was found in NB4 cells after treatment with quercetin. Apoptotic marker Annexin V analysis showed that the apoptotic rate of NB4 cells was increased after treatment with quercetin. The secretion of VEGF of NB4 cells was significantly decreased after treatment with quercetin.</p><p><b>CONCLUSION</b>Quercetin can induce apoptosis and inhibit secretion of VEGF in NB4 leukemia cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Quercetin
/
Leukemia, Myeloid, Acute
/
Apoptosis
/
Bodily Secretions
/
Cell Line, Tumor
/
Vascular Endothelial Growth Factor A
/
Metabolism
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2006
Type:
Article
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