Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 713-716, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-308456
ABSTRACT
<p><b>OBJECTIVE</b>To assess the relationship between the XRCC1 polymorphism and susceptibility to lung cancer in non-smoking female on the basis of a hospital-based case-control study.</p><p><b>METHODS</b>Genotypes were determined by PCR-restriction fragment length polymorphism in 50 patients with lung cancer and 50 controls. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression model to study the relationship between different genotypes and risk of lung cancer in non-smoking women. Furthermore, a multiplicative interaction between exposure to cooking oil smoke and the variant XRCC1 399Gln allele on risk of lung adenocarcinoma was evaluated.</p><p><b>RESULTS</b>Individuals carrying Gln/Gln genotype were at an increased risk to suffer from lung adenocarcinoma as compared with those with the Arg/Arg genotype (OR 14.12; 95% CI 2.14 approximately 92.95, adjusted for age and cooking oil smoke). The OR of lung adenocarcinoma for the variant XRCC1 399Gln allele with exposure to cooking oil smoke was 6.29 (95% CI 1.99 approximately 19.85).</p><p><b>CONCLUSION</b>The above described findings indicate that Arg 399Gln polymorphism in the XRCC1 is associated with risk of lung adenocarcinoma but not with risk of squamous-cell carcinoma of the lung in non-smoking women.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Smoking
/
Case-Control Studies
/
Air Pollution, Indoor
/
Risk Assessment
/
Cooking
/
Genetic Predisposition to Disease
/
DNA-Binding Proteins
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2005
Type:
Article
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