Study on effect of total coumarins from Urtica dentata on dextran sulfate sodium-induced colitis in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3316-3320, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-308593
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of total coumarins (TC) from Urtica dentata on dextran sulfate sodium (DSS)-induced colitis in mice.</p><p><b>METHOD</b>The colitis model was established by administering DSS. Having been treated with TC, their body weight was determined. Concentrations of IL-6, IL-10, TGF-beta1 and IFN-gamma were monitored by ELISA. Colon samples were collected for the histopathological examination. Western blot was used to detect TLR4 and NF-kappaB protein expression in colonic tissues.</p><p><b>RESULT</b>TCs from U. dentata effectively controlled the body weight loss of mice with colitis, down-regulated the concentration of IL-6 and IFN-gamma and increased the suppressive cytokines IL-10 and TGF-beta1 in the serum. Additionally, TC alleviated the mucosal damage and decreased the expressions of TLR4 and NF-kappaB in colonic tissues.</p><p><b>CONCLUSION</b>TCs from U. dentata shows the anti-inflammatory effect on colitis in mice by reducing the expressions of TLR4 and NF-kappaB in colonic tissues and regulating pro-and anti-inflammatory cytokines.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Chemistry
/
Cytokines
/
Dextran Sulfate
/
NF-kappa B
/
Colitis
/
Coumarins
/
Urticaceae
/
Therapeutic Uses
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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