Application of BeWo cell model in studies on placental transport mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3193-3197, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-308619
ABSTRACT
As placenta barrier controls material exchanges between mother and fetus during pregnancy, studies on the placental transport mechanism of drugs is of great importance to analyze the efficacy, safety and toxicity of drugs. BeWo cells are derived from human choriocarcinomas, which can form monolayer trophoblast cells to offers an efficient placenta barrier in vitro for estimating nutrient and drug intake, efflux and transport. This essay focuses on the establishment and characteristics of BeWo cell model, and the advance on studies on nutrient and drug intake, efflux and transport mechanism by applying the model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Uterine Neoplasms
/
Biological Transport
/
Tumor Cells, Cultured
/
Choriocarcinoma
/
Metabolism
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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