A Case of Hodgkin Lymphoma Developed in an Ataxia-telangiectasia Patient / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 184-187, 2016.
Article
in English
| WPRIM
| ID: wpr-30879
ABSTRACT
Ataxia-telangiectasia (AT) is characterized by cerebellar ataxia, progressive immunodeficiency, radiation sensitivity, telangiectasia, and predisposition to malignancy. AT patients have a 100-fold increased risk for the development of lymphoid malignancies. It is important to consider AT in a child with pre-existing ataxia, or lymphoid malignancy that was diagnosed at a younger age than expected. This consideration avoids the confusion between ataxia development and toxicity from chemotherapy. Hodgkin's lymphoma (HL) is usually treated with chemotherapy and/or radiotherapy. Unfortunately, when treated with conventional doses of radiotherapy, AT patients invariably experience devastating necrosis of their normal tissues. Therefore, a new treatment protocol for patients with HL in AT must be established. In this paper, we report the case of an 8-year-old female patient with HL in AT who was treated with chemotherapy. This patient was also treated with brentuximab (which targets CD30) for salvage therapy after the disease progressed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation Tolerance
/
Radiotherapy
/
Ataxia
/
Telangiectasis
/
Ataxia Telangiectasia
/
Hodgkin Disease
/
Cerebellar Ataxia
/
Clinical Protocols
/
Salvage Therapy
/
Drug Therapy
Type of study:
Practice guideline
Limits:
Child
/
Female
/
Humans
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2016
Type:
Article
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