Your browser doesn't support javascript.
loading
Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 282-284, 2011.
Article in Chinese | WPRIM | ID: wpr-308811
ABSTRACT
<p><b>OBJECTIVE</b>To study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>The flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children.</p><p><b>RESULTS</b>The expression levels of CD4+CD25+CD127-[(2.7±1.7)% vs (4.8±1.6)%; P<0.01]and CD3+CD4-CD8-[(5.2±3.1)% vs (8.1±3.5)%; P<0.01]Treg cells in children with ITP were significantly lower than in the controls.</p><p><b>CONCLUSIONS</b>The expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: CD4 Antigens / Purpura, Thrombocytopenic, Idiopathic / CD3 Complex / T-Lymphocytes, Regulatory / Allergy and Immunology / Interleukin-2 Receptor alpha Subunit / Interleukin-7 Receptor alpha Subunit / Flow Cytometry Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: CD4 Antigens / Purpura, Thrombocytopenic, Idiopathic / CD3 Complex / T-Lymphocytes, Regulatory / Allergy and Immunology / Interleukin-2 Receptor alpha Subunit / Interleukin-7 Receptor alpha Subunit / Flow Cytometry Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2011 Type: Article