Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 282-284, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-308811
ABSTRACT
<p><b>OBJECTIVE</b>To study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>The flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children.</p><p><b>RESULTS</b>The expression levels of CD4+CD25+CD127-[(2.7±1.7)% vs (4.8±1.6)%; P<0.01]and CD3+CD4-CD8-[(5.2±3.1)% vs (8.1±3.5)%; P<0.01]Treg cells in children with ITP were significantly lower than in the controls.</p><p><b>CONCLUSIONS</b>The expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
CD4 Antigens
/
Purpura, Thrombocytopenic, Idiopathic
/
CD3 Complex
/
T-Lymphocytes, Regulatory
/
Allergy and Immunology
/
Interleukin-2 Receptor alpha Subunit
/
Interleukin-7 Receptor alpha Subunit
/
Flow Cytometry
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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