Serum levels of HIF-1α, ET-1 and Ca(2+) in neonates with hypoxic pulmonary hypertension / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 181-184, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-308840
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes and significance of serum hypoxia-inducible factor-1α (HIF-1α), endothelin-1 (ET-1) and calcium (Ca(2+)) levels in neonates with hypoxic pulmonary hypertension (HPH).</p><p><b>METHODS</b>Seventy-five neonates with HPH (29 mild, 25 moderate and 21 severe) and 22 hospitalized neonates with non-HPH (control group) were enrolled. Pulmonary artery systolic blood pressure (PASP) was measured by bedside echocardiography within 24 hrs after birth. Serum levels of HIF-1α and ET-1 were measured using ELASA. Serum Ca2+ concentrations were measured with ion selective electrode.</p><p><b>RESULTS</b>Serum levels of HIF-1α and ET-1 in the HPH group increased significantly compared with those in the control group (P<0.01), and were positively related with PASP (Rhif-1α=0.75, P<0.01; Ret-1=0.56,P<0.05). Serum Ca2+ levels in neonates with severe HPH were significantly lower than those in the control group (P<0.05). There were no correlation between serum Ca2+ levels and PASP.</p><p><b>CONCLUSIONS</b>Serum HIF-1α and ET-1 levels are positively related with PASP in neonates with HPH, suggesting that serum HIF-1α and ET-1 may be involved in the occurrence of neonatal HPH. Serum Ca2+ levels are reduced in severe neonates with HPH, suggesting that serum Ca2+ may play a role in the occurrence of severe HPH.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Pulmonary Artery
/
Blood
/
Blood Pressure
/
Calcium
/
Endothelin-1
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hypertension, Pulmonary
/
Hypoxia
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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