Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 307-313, 2007.
Article
in English
| WPRIM
| ID: wpr-309000
ABSTRACT
<p><b>OBJECTIVE</b>To conduct a randomized comparative trial of pharmacokinetics, efficacy and toxicity profile treatment with 1200 mg/m(2) gemcitabine using standard 30-min infusion or fixed dose rate (FDR) infusion [10 mg/(m(2) x min)] on days 1 and 8 plus carboplatin AUC (area under curve) 5 on day 1 in Chinese non-small-cell cancer patients. Twelve patients were enrolled in this study.</p><p><b>METHODS</b>Plasma gemcitabine concentrations were measured by ion-pair reversed phase high performance liquid chromatography. Antitumoral activity and toxicity of gemcitabine was assessed according to World Health Organization criteria.</p><p><b>RESULTS</b>The obtained mean parameters, such as T(1/2) (elimination half time), AUC, and CL (clearance), were consistent with those reported in literature. Qualified response rate in our study was 33.3% for standard arm and 50% for FDR arm. Additional 50% and 33.3% patients contracted stable disease (SD) in standard arm and FDR arm, respectively. The predominant toxicity was hematologic, and patients in the standard infusion arm experienced consistently more hematologic toxicity.</p><p><b>CONCLUSION</b>Pharmacokinetic and clinical data in this trial support the continued evaluation of the FDR infusion strategy with gemcitabine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Administration Schedule
/
Pharmacokinetics
/
Treatment Outcome
/
Carcinoma, Non-Small-Cell Lung
/
Asian People
/
Deoxycytidine
/
Dose-Response Relationship, Drug
/
Drug Therapy
/
Hematologic Diseases
/
Lung Neoplasms
Type of study:
Controlled clinical trial
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2007
Type:
Article
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