Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 998-1005, 2006.
Article
in English
| WPRIM
| ID: wpr-309044
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.</p><p><b>METHODS</b>Different doses (1.25, 2.5 and 5 mg/kg, i.p.) of MRZ2/576 were used to evaluate the effect of MRZ2/576 on the acquisition and expression of CPP induced by morphine (5 mg/kg) in mice. In addition, we examined the locomotor activity of mice in conditioning and testing phase of CPP paradigm.</p><p><b>RESULTS</b>MRZ2/576 alone could not establish place preference, but a 5 mg/kg dose of MRZ2/576 could block both acquisition and expression of morphine-induced CPP. In testing phase of CPP, there was no statistical difference for locomotor activity between the groups; injection of MRZ2/576 showed a dose-dependent decrease of locomotor activity on both control and morphine-treated mice, especially 5 mg/kg of MRZ2/576 significantly suppressed the locomotor activity of mice.</p><p><b>CONCLUSION</b>Based on the present results, we assume that MRZ2/576 can antagonize the rewarding effect of morphine, suggesting that this glycine site/NMDA receptor antagonist could be used to treat addictions due to its light side effect profile.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phthalazines
/
Physiology
/
Receptors, N-Methyl-D-Aspartate
/
Excitatory Amino Acid Antagonists
/
Conditioning, Psychological
/
Magnesium
/
Mice, Inbred ICR
/
Morphine
/
Motor Activity
Limits:
Animals
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2006
Type:
Article
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