Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 639-642, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-309088
ABSTRACT
The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This review summarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilage repair.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Cartilage
/
Chondrocytes
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hypoxia
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2016
Type:
Article
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