DAZL and male infertility: an update / 中华男科学杂志
National Journal of Andrology
;
(12): 647-650, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-309660
ABSTRACT
DAZL, a member of the DAZ family, plays a key role in human spermatogenesis. It regulates the promoter via genetic modification, especially DNA methylation, promoting the transcription of DAZL. Besides, the relation of DAZL SNPs with male infertility has been a hot spot of research for many years. It is deduced that local and ethnic factors may be associated with the failure of spermatogenesis. This article presents an overview on the results of recent studies, changes in the DNA methylation of DAZL in spermatogenesis, and the association of DAZL SNPs with male infertility, aiming to provide a new theoretical basis and clinical strategy for the treatment of male infertility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
RNA-Binding Proteins
/
DNA Methylation
/
Polymorphism, Single Nucleotide
/
Genetics
/
Infertility, Male
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2014
Type:
Article
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