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Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia / 中华男科学杂志
National Journal of Andrology ; (12): 419-422, 2014.
Article in Chinese | WPRIM | ID: wpr-309696
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.</p><p><b>METHODS</b>Using MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.</p><p><b>RESULTS</b>The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).</p><p><b>CONCLUSION</b>The ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / China / Polymorphism, Single Nucleotide / DNA Repair / Xeroderma Pigmentosum Group D Protein / Genetics / Genotype / Infertility, Male Type of study: Observational study / Risk factors Limits: Adult / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: National Journal of Andrology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / China / Polymorphism, Single Nucleotide / DNA Repair / Xeroderma Pigmentosum Group D Protein / Genetics / Genotype / Infertility, Male Type of study: Observational study / Risk factors Limits: Adult / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: National Journal of Andrology Year: 2014 Type: Article