Epigenetic regulation in spermatogenesis / 中华男科学杂志
National Journal of Andrology
;
(12): 387-391, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-309702
ABSTRACT
Spermatogenesis is a process consisting of spermatogonial proliferation, spermatocytic meiosis, and spermiogenesis, and is also considered to be a process in which heterochromatins gradually aggregate and finally reach a highly condensed formation in the sperm head. Recent studies show that epigenetic regulation plays a key role in spermatogenesis. This review discusses the mechanisms of epigenetic regulation in spermatogenesis in three aspects, DNA methylation, histone modification, and noncoding RNAs. These factors are essential for spermatogenesis, fertilization, and embryogenesis by mutual regulation as well as by gene expression regulation, transposon activation, sex chromosome inactivation, and genome imprinting.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Spermatogenesis
/
Spermatogonia
/
Genomic Imprinting
/
DNA Methylation
/
Cell Biology
/
Epigenesis, Genetic
/
Embryonic Development
/
Genetics
/
Meiosis
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2014
Type:
Article
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