Common TCM syndrome pattern of chronic pelvic pain syndrome relates to plasma substance p and beta endorphin / 中华男科学杂志
National Journal of Andrology
;
(12): 363-366, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-309705
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of the common Traditional Chinese Medicine (TCM) syndrome pattern of chronic pelvic pain syndrome (CPPS) with the contents of substance p and beta endorphin in the plasma, and provide reference data for the clinical diagnosis, differentiation and treatment of CPPS by TCM.</p><p><b>METHODS</b>We observed 98 cases of CPPS, which were classified into a lower-part damp-heat invasion group (group A, n = 32), a blood stasis-induced collateral obstruction group (group B, n = 34), and a damp-heat stagnation group (group C, n = 32) according to the TCM syndrome differentiation. Another 35 normal healthy young men were enrolled as controls. We measured the contents of substance p and beta endorphin in the plasma by immunoradiometry and ELISA, and analyzed their relationship with the TCM syndrome pattern.</p><p><b>RESULTS</b>The contents of plasma substance p were significantly higher in groups A ([1135.76 +/- 166.45] pg/ml), B ([1 337.84 +/- 170.81] pg/ml), and C ([1 210.01 +/- 162.27] pg/ml) than in the control ([574.99 +/- 113.09] pg/ml) (all P < 0.01), while the contents of plasma beta endorphin in groups A ([212.70 +/- 29.49] pg/ml), B ([157.99 +/- 24.01] pg/ml), and C ([180.81 +/- 20.20] pg/ml) were remarkably lower than that in the control ([274.73 +/- 27.64] pg/ml) (all P < 0.01).</p><p><b>CONCLUSION</b>In the plasma of CPPS patients, the content of substance p is significantly elevated and that of beta endorphin markedly reduced, which suggests that they may be involved in the inflammatory reaction of CPPS. The levels of plasma substance p and beta endorphin can be used as valuable reference for the TCM classification of chronic prostatitis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatitis
/
Syndrome
/
Blood
/
Beta-Endorphin
/
Substance P
/
Case-Control Studies
/
Chronic Disease
/
Classification
/
Pelvic Pain
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2014
Type:
Article
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