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A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2) / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine ; : 223-226, 2006.
Article in Korean | WPRIM | ID: wpr-30976
ABSTRACT
ider(9)(q10)t(9;22)(q34;q11.2) is an isochromosome for the long arm of a derivative chromosome 9 generated by a t(9;22), resulting from the deletion of the short arm of chromosome 9. It is known to be rarely observed in acute lymphoblastic leukemia (ALL) or lymphoblastic crisis transformed from chronic myelogenous leukemia. We herein describe a 26-year-old female patient with precursor B-cell ALL, cytogenetically characterized by ider(9)(q10)t(9;22). Fluorescence in situ hybridization analysis showed two ABL-BCR fusion signals on the derivative chromosome 9 and one BCR-ABL fusion signal on the derivative chromosome 22. Although a t(9;22) and a deletion of the short arm of chromosome 9 are known to be associated with a poor prognostic factor in acute lymphoblastic leukemia, a larger study is needed to determine the prognosis of ider(9)(q10)t(9;22) cases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arm / Prognosis / Chromosomes, Human, Pair 9 / Chromosomes, Human, Pair 22 / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / In Situ Hybridization / Isochromosomes / Precursor Cells, B-Lymphoid / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Fluorescence Type of study: Prognostic study Limits: Adult / Female / Humans Language: Korean Journal: The Korean Journal of Laboratory Medicine Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arm / Prognosis / Chromosomes, Human, Pair 9 / Chromosomes, Human, Pair 22 / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / In Situ Hybridization / Isochromosomes / Precursor Cells, B-Lymphoid / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Fluorescence Type of study: Prognostic study Limits: Adult / Female / Humans Language: Korean Journal: The Korean Journal of Laboratory Medicine Year: 2006 Type: Article