Strontium-89: a desirable therapeutic for bone metastases of prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 819-822, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-309787
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of strontium-89 (89Sr) in the treatment of painful bone metastases of prostate cancer.</p><p><b>METHODS</b>A total of 116 patients with painful bone metastases of prostate cancer received bilateral orchiectomy and incretion, followed by intravenous injection of 89Sr at the dose of 1.48-2.22 MBq (40-60 microCi)/kg. The clinical effects were evaluated by follow-up analysis.</p><p><b>RESULTS</b>After the 89Sr treatment, appetite and sleep were evidently improved in 33.6% and 56.0% of the patients respectively, the applied dose of anodyne reduced in 61.2%, pain alleviated in 83.6%, with an absolute palliation rate of 24.1%. Pain relief started at 3-21 (10.2 +/- 6.5) days and lasted 3-12 (5.3 +/- 2.2) months. Flare ache occurred in 31.9% of the patients. Compared with pre-treatment, the mean score on Karnofsky's performance status (KPS) was 20.0% higher, and the WBC count decreased to 3.0-3.9 x 10(6)/L in 18.1% of the patients. Whole body bone scintigraphy of 53 followed-up patients showed that 39 (73.6%) of them exhibited an obvious decrease in the number of metastases, 10 (18.9% remained in a stabilized state and only 4 (7.5% deteriorated.</p><p><b>CONCLUSION</b>89Sr, capable of inhibiting bone metastasis, palliating pain and improving the quality of life with few adverse effects, can be used as a desirable therapeutic for painful bone metastases of prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Intractable
/
Pathology
/
Prostatic Neoplasms
/
Radiotherapy
/
Strontium Radioisotopes
/
Bone Neoplasms
/
Follow-Up Studies
/
Treatment Outcome
/
Therapeutic Uses
Type of study:
Observational study
/
Prognostic study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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