Nitric oxide synthetase and carbon monoxide decrease in the penile corpus cavernous of hyper homocysteine rats / 中华男科学杂志
National Journal of Andrology
;
(12): 701-703, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-309811
ABSTRACT
<p><b>OBJECTIVE</b>To detect the levels of nitric oxide synthetase (NOS) and carbon monoxide (CO) in the penile corpus cavernous of adult male Wistar rats with high homocysteine (Hhcy) and to explore the relationship of NOS and CO levels with erectile dysfunction.</p><p><b>METHODS</b>Twenty Wistar rats were equally and randomly divided into a control and an Hhcy group and fed on normal diet and normal diet with 3.0% methionine respectively. Four weeks later, the levels of NOS and CO in the penile corpus cavernous were detected by ultraviolet spectrophotometry and that of serum homocysteine by the cycle enzyme method.</p><p><b>RESULTS</b>Compared with the control group, the levels of NOS and CO in the penile corpus cavernous were significantly lower in the Hhcy group, (6.45 +/- 1.12) nmol/(g x min) vs (10.77 +/- 0.60) nmol/(g x min) and (10.60 +/- 0.92) micromol/L vs (13.36 +/- 0.44) micromol/L, while that of homocysteine was significantly higher, (22.32 +/- 1.65) micromol/L) vs (4.90 +/- 1.73) micromol/L.</p><p><b>CONCLUSION</b>Four-week diet with methionine can cause Hhcy and significantly decreased levels of NOS and CO in the penile corpus cavernous in Wistar rats. Hhcy is an independent risk factor of erectile dysfunction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penis
/
Spectrophotometry, Ultraviolet
/
Blood
/
Carbon Monoxide
/
Rats, Wistar
/
Nitric Oxide Synthase
/
Hyperhomocysteinemia
/
Homocysteine
/
Metabolism
Type of study:
Risk factors
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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