Progress and perspectives on targeting nanoparticles for brain drug delivery
Acta Pharmaceutica Sinica B
;
(6): 268-286, 2016.
Article
in English
| WPRIM
| ID: wpr-309957
ABSTRACT
Due to the ability of the blood-brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood-brain tumor barrier (BBTB), and nose-to-brain barrier. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Acta Pharmaceutica Sinica B
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS