Pharmacoeconomic evaluation of telbivudine vs. lamivudine in treating the patients with HBeAg-positive and negative chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 569-573, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310044
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate long-term cost effectiveness of telbivudine and lamivudine for the treatment of CHB.</p><p><b>METHODS</b>Cost effectiveness was conducted from social health insurance perspective. A Markov model was established based on disease progression pattern and the data from the 2 years GLOBE clinical trial. The information of annual medical expenditure and quality-of-life assessment for different CHB-related diseases was obtained from literature. Incremental cost per life year or quality-adjusted life year gained was measured.</p><p><b>RESULTS</b>Compared with lamivudine, the incremental cost for 1 additional QALY gained with telbivudine in treating HBeAg-positive and -negative CHB were 5403 yuan and 28239 yuan in Beijing, as well 4916 yuan and 29618 yuan in Guangzhou, respectively. According to national economic burden of CHB-related diseases, the ICER with telbivudine vs lamivudine were 1282 yuan and 31565 yuan for HBeAg-positive and -negative CHB.</p><p><b>CONCLUSION</b>According to WHO recommendation for ICER threshold, telbivudine is cost effective in treating HBeAg-positive and -negative CHB, as compared to lamivudine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrimidinones
/
Thymidine
/
Blood
/
DNA, Viral
/
China
/
Epidemiology
/
Markov Chains
/
Drug Costs
/
Cost-Benefit Analysis
/
Insurance, Long-Term Care
Type of study:
Controlled clinical trial
/
Practice guideline
/
Health economic evaluation
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2009
Type:
Article
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