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Effects of PLGA absorbable membrane on preventing postoperative abdominal adhesion in rabbits / 中国医疗器械杂志
Article in Zh | WPRIM | ID: wpr-310315
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of PLGA absorbable membrane in prevention of postoperative abdominal adhesion in rabbits.</p><p><b>METHODS</b>66 Japanese white rabbits were randomly divided into three groups: the normal control group n = 6, model control group n = 30 and PLGA group n = 30. Rabbits were received multifactor methods to establish postoperative abdominal adhesion models except for normal control group. The cecum wound was covered PLGA membrane in the PLGA group. At postoperative 1, 2, 4, 6 and 12 weeks, the abdominal cavities were reopened and the adhesive severity was graded blindly, and the hydroxyproline level in cecum tissue was measured and the cecum histopathology was observed.</p><p><b>RESULTS</b>(1) the degree of adhesion and hydroxyproline level in model control group were significantly higher than those of normal control group (P < 0.05, P < 0.01), while the degree of adhesion and hydroxyproline level in PLGA group were significantly lower than those of model control group (P < 0.05). (2) HE staining showed that cecum serosa had obviously inflammatory cell infiltration and fibroblast proliferation, while PLGA could inhibit fibroblast proliferation and reduce the inflammatory cell infiltration and collagen.</p><p><b>CONCLUSION</b>PLGA absorbable membrane can inhibit fibroblast proliferation and collagen to prevent the experimental postoperative peritoneal adhesions.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pathology / Polyglycolic Acid / Postoperative Complications / Chemistry / Tissue Adhesions / Collagen / Lactic Acid / Cell Biology / Abdominal Cavity / Cell Proliferation Limits: Animals Language: Zh Journal: Chinese Journal of Medical Instrumentation Year: 2014 Type: Article
Full text: 1 Index: WPRIM Main subject: Pathology / Polyglycolic Acid / Postoperative Complications / Chemistry / Tissue Adhesions / Collagen / Lactic Acid / Cell Biology / Abdominal Cavity / Cell Proliferation Limits: Animals Language: Zh Journal: Chinese Journal of Medical Instrumentation Year: 2014 Type: Article