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Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 352-356, 2009.
Article in Chinese | WPRIM | ID: wpr-310341
ABSTRACT
<p><b>OBJECTIVE</b>To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance.</p><p><b>METHODS</b>Serum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA.</p><p><b>RESULTS</b>IL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01).</p><p><b>CONCLUSION</b>A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cytokines / Interleukin-4 / Interferon-gamma / Leukotriene B4 / Th2 Cells / Th1 Cells / Interleukin-13 / Chemokines / Allergy and Immunology Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cytokines / Interleukin-4 / Interferon-gamma / Leukotriene B4 / Th2 Cells / Th1 Cells / Interleukin-13 / Chemokines / Allergy and Immunology Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2009 Type: Article