Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 352-356, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310341
ABSTRACT
<p><b>OBJECTIVE</b>To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance.</p><p><b>METHODS</b>Serum levels of IFN-gamma, IL-4, IL-5, IL-13, Eotaxin, RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA.</p><p><b>RESULTS</b>IL-4, IL-5, IL-13 and Eotaxin, LTB4 were increased significantly in serum of allergic patients compared with those of controls (P<0.05). There were no significant differences in serum levels of IFN-gamma and RANTES between patients and controls (P>0.05). Serum levels of IL-4, IL-5, IL-13 and LTB4 were correlated with each other (P<0.01). Eotaxin, RANTES and IFN-gamma levels were also significantly correlated with each other (P<0.05). LTB4 was correlated with Eotaxin as well (P<0.01).</p><p><b>CONCLUSION</b>A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Cytokines
/
Interleukin-4
/
Interferon-gamma
/
Leukotriene B4
/
Th2 Cells
/
Th1 Cells
/
Interleukin-13
/
Chemokines
/
Allergy and Immunology
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
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