Effects of 8-Methoxypsoralen on intracellular Ca(2+)i and cytoskeleton actin organization in human melanocytes in vitro / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 348-351, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310342
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of 8-methoxypsoralen on human melanocytes [Ca(2+)]i and cytoskeleton actin organization in vitro.</p><p><b>METHODS</b>Human melanocytes were obtained from normal foreskins. Laser confocal microscope was employed to measure [Ca(2+)]i and rhodamine-conjugated phalloidin was used to visualize the cytoskeleton actin.</p><p><b>RESULTS</b>8-methoxypsoralen increased [Ca(2+)]i and induced organization of actin stress fiber cytoskeleton.</p><p><b>CONCLUSION</b>8-methoxypsoralen might influence the migration of melanocytes by increasing the intracellular free Ca(2+) concentration and cytoskeleton actin reorganization.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Skin
/
Cell Movement
/
Cells, Cultured
/
Calcium
/
Actins
/
Cell Biology
/
Cytoskeletal Proteins
/
Genetics
/
Melanocytes
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
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