Meta-analysis on peginterferon plus ribavirin in treatment of hepatitis C virus genotype 1 or 4 infection in HIV patients / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 315-319, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310348
ABSTRACT
<p><b>OBJECTIVE</b>To perform a Meta-analysis on peginterferon with interferon in treatment of HIV patients coinfected with refractory genotype HCV.</p><p><b>METHODS</b>A literature search of Medline was conducted to identify eligible randomized controlled trials. Meta analysis was conducted to evaluate peginterferon and interferon in treatment of coinfected HCV genotype 1 or 4 in HIV patients.</p><p><b>RESULT</b>Six trials of 88 matched the selection criteria. Total 1,131 patients with coinfection of HCV genotype 1 or 4 and HIV were included. Sustain viral response was higher in patients treated with peginterferon plus ribavirin compared with that of interferon plus ribavirin (26 % compared with 8 %) or peginterferon alone (26 % compared with 13 %). Severe adverse effects and withdrawal rates were similar for patients treated with peginterferon and patients treated with interferon.</p><p><b>CONCLUSION</b>Peginterferon plus ribavirin in treatment of patients with coinfection of genotype 1 or 4 HCV and HIV can achieve higher sustain viral response and the likelihoods of serious adverse effects and withdrawal rates are similar to other therapies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Polyethylene Glycols
/
Ribavirin
/
Virology
/
Recombinant Proteins
/
HIV Infections
/
Randomized Controlled Trials as Topic
/
Classification
/
Interferon-alpha
/
Hepacivirus
Type of study:
Controlled clinical trial
/
Prognostic study
/
Systematic reviews
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
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