Establishment of reflux esophagitis models in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 297-304, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310351
ABSTRACT
<p><b>OBJECTIVE</b>To establish animal models of reflux esophagitis in rats.</p><p><b>METHODS</b>Seventy male Sprague Dawley rats aged 8 weeks were randomly divided into 4 groups in Group A (n=20) esophagojejunostomy was performed to induce a gastro-jejuno-esophageal reflux; in Group B (n=20) esophagoduodenostomy was performed to induce a gastro-duodeno-esophageal reflux; in Group C (n=20) total gastrectomy plus esophagojejunostomy was performed to induce a jejuno-esophageal reflux; in Group D (n=10) only was performed sham operation (control).</p><p><b>RESULT</b>Among 70 rats, 6 died in Group A, 7 died in Group B, 6 died in Group C, and 72.9 %(51/70) animals were completed in the study. After 12 weeks the incidence of esophageal inflammation was 100.0%; in Groups A, B and C erosion occurred in 11/14 (78.6%), 10/13 (76.9%), 3/14 (21.4%) of animals, respectively; squamous dysplasia was in 10/14 (71.4%), 10/13 (76.9%), 5/14 (35.7%) of rats, respectively; Barrett's esophagus was in 6/14 (42.9%), 5/13 (38.5%), 1/14 (7.1%), respectively. One esophageal adenocarcinoma was found in Group A; no histological changes were observed in Group D.</p><p><b>CONCLUSION</b>The animal models of reflux esophagitis can be induced by esophagojejunostomy, esophagoduodenostomy or total gastrectomy plus esophago-jejunostomy in rats; and the former two surgical modalities are better than the later.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Barrett Esophagus
/
Esophagitis, Peptic
/
Random Allocation
/
Classification
/
Rats, Sprague-Dawley
/
Disease Models, Animal
/
Esophagus
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS