Drug permeability through buccal mucosa / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 181-185, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310370
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of physicochemical properties of drug on its permeability through buccal mucosa.</p><p><b>METHODS</b>Benzoic acid, caffeine and hydrocortisone were selected as model drugs and their permeability coefficients through isolated porcine buccal mucosa were determined.</p><p><b>RESULT</b>The permeability coefficients of benzoic acid, caffeine and hydrocortisone through isolated porcine buccal mucosa were (1.01 x 10(-4)+/-1.64 x 10(-5))cm.s(-1)ì(2.75 x 10(-5)+/-1.79 x 10(-6))cm.s(-1) and (2.49 x 10(-5)+/-6.32 x 10(-6))cm.s(-1), which were 14,989 and 389 times as those through human skin, respectively.</p><p><b>CONCLUSION</b>The permeability of drugs through buccal mucosa seems to be much better than that through human skin.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Swine
/
In Vitro Techniques
/
Caffeine
/
Hydrocortisone
/
Pharmacokinetics
/
Benzoic Acid
/
Metabolism
/
Mouth Mucosa
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS