Preparation of floxuridine loaded polycation and its antitumor activity / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 53-58, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310391
ABSTRACT
<p><b>OBJECTIVE</b>To develop a new prodrug of 5-fluorouracil-polyethylenimine-beta-cyclodextrin-floxuridine (PEI-beta-CyD-Fd) and to test its antitumor activity.</p><p><b>METHODS</b>Floxuridine was conjugated to polyethylenimine-beta-cyclodextrin to form prodrug PEI-beta-CyD-Fd. The structure of synthesized PEI-beta-CyD-Fd was confirmed by (1)H-NMR, FT-IR and UV. MTT assay and cell wound healing assay were performed on human hepatic carcinoma cell line HepG2.</p><p><b>RESULT</b>The drug loading was 2 %. The MTT assay and cell wound healing assay indicated that PEI-beta-CyD-Fd significantly inhibited proliferation and migration of HepG2 cells.</p><p><b>CONCLUSION</b>The synthesized prodrug PEI-CyD-Fd has a significant antitumor activity on HepG2 cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Polyethyleneimine
/
Prodrugs
/
Cell Movement
/
Floxuridine
/
Cell Line, Tumor
/
Beta-Cyclodextrins
/
Cell Proliferation
/
Fluorouracil
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS