Effects of amygdala kindled seizures on memory retention of passive-avoidance test in rats / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of amygdala kindled seizures on memory retention of passive-avoidance test in rats.</p><p><b>METHODS</b>Chronic kindled seizures were achieved by daily application of electric stimulations on amygdala until the occurrence of 3 consecutive convulsive seizures. Then a passive-avoidance test was performed to measure memory retention ability in rats; another group of rats received an electric stimulation on amygdala 5 min before the training trail to observe the effects of acute seizure attack on memory retention ability.</p><p><b>RESULT</b>In the training trail and the 1st day of the test trail, there was no difference in the latency to enter dark compartment between chronic kindled seizure group and its corresponding control group. However, the latency significantly increased at the 5 th day of test trail. In addition, the latency of acute seizure attack group rats significantly decreased at the 1 st day and 5 th day of test trail.</p><p><b>CONCLUSION</b>Chronic amygdala kindled seizures increase memory retention of passive-avoidance test in rats, and acute seizure attack impairs this action.</p>