Prostate cancer antigen-1 as a potential novel marker for prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 821-826, 2007.
Article
in English
| WPRIM
| ID: wpr-310446
ABSTRACT
<p><b>AIM</b>To examine the expression of prostate cancer antigen-1 (PCA-1) in prostate cancer (PCa) and to validate it as a potential marker for diagnosis of PCa.</p><p><b>METHODS</b>In situ hybridization analysis of PCA-1 mRNA expression was performed on 40 benign prostate hyperplasia (BPH), 16 high-grade prostatic intraepithelial neoplasm (HG-PIN), 74 PCa and 34 other malignant carcinoma specimens. The level of PCA-1 expression was semiquantitatively scored by assessing both the percentage and intensity of PCA-1 positive staining cells in the specimens. We then compared the PCA-1 expression between BPH, HG-PIN and PCa and evaluated the correlation of PCA-1 expression level with clinical parameters of PCa.</p><p><b>RESULTS</b>PCA-1 mRNA was expressed in the majority of both PCa and HG-PIN specimens but not in BPH and other malignant carcinoma. The expression level of PCA-1 increased along with a high Gleason score (P < 0.05), and was unrelated to other clinical parameters of PCa (all P > 0.05).</p><p><b>CONCLUSION</b>The data suggest that PCA-1 might be a novel diagnostic marker for PCa, and that increased PCA-1 expression might denote more aggressive variants of PCa.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Biopsy
/
RNA, Messenger
/
Biomarkers, Tumor
/
DNA, Complementary
/
Prostatic Intraepithelial Neoplasia
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2007
Type:
Article
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