Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 331-338, 2007.
Article
in English
| WPRIM
| ID: wpr-310506
ABSTRACT
<p><b>AIM</b>To investigate the association among XRCC1 polymorphisms, smoking, drinking and the risk of prostate cancer (PCa) in men from Han, Southern China.</p><p><b>METHODS</b>In a case-control study of 207 patients with PCa and 235 cancer-free controls, frequency-matched by age, we genotyped three XRCC1 polymorphisms (codons 194, 280 and 399) using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) method.</p><p><b>RESULTS</b>Among the three polymorphisms, we found that the XRCC1 Arg399Gln variant allele was associated with increased PCa risk (adjusted odd ratio [OR] 1.67, 95% confident interval [CI] 1.11-2.51), but the XRCC1 Arg194Trp variant allele had a 38% reduction in risk of PCa (adjusted OR 0.62, 95% CI 0.41-0.93). However, there was no significant risk of PCa associated with Arg280His polymorphism. When we evaluated the three polymorphisms together, we found that the individuals with 194Arg/Arg wild-type genotype, Arg280His and Arg399Gln variant genotypes had a significantly higher risk of PCa (adjusted OR 4.31; 95% CI 1.24-14.99) than those with three wild-type genotypes. In addition, we found that Arg399Gln variant genotypes had a significant risk of PCa among heavy smokers (adjusted OR 2.04; 95% CI 1.03-4.05).</p><p><b>CONCLUSION</b>These results suggest that polymorphisms of XRCC1 appear to influence the risk of PCa and may modify risks attributable to environmental exposure.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Neoplasms
/
Blood
/
Polymorphism, Restriction Fragment Length
/
Adenocarcinoma
/
Odds Ratio
/
Seroepidemiologic Studies
/
China
/
Epidemiology
/
Risk Factors
/
Genetic Predisposition to Disease
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Aged
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Journal of Andrology
Year:
2007
Type:
Article
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